University of California

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The Government of the United States of America

Greg Nelson

Charles S Zuker

Mark A Hoon

Nicholas J P Ryba

Yifeng Zhang

Jayaram Chandrashekar

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors

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San Diego, CA, United States of America

Greg Nelson