Genetic Systems Corporation

Virginia Mason Research Center

Gerald T Nepom

Barbara S Nepom

Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2 allele. This method involves estimating the size of the hybridizable DNA fragment generated by a specific restriction endonuclease and therefrom determining the presence of the allele. A second preferred method involves the serologic detection of the DQw3.2 allele. Within this method, immunocomplexes formed between two different MAb's and separate portions of a cell collection are detected and the presence or absence of the allele determined.

Methods for identifying the DQw3.2 allele associated with increased risk

Oligonucleotide probes for diagnosing predisposition to rheumatoid arthritis, capable of specifically hybridizing with

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Bainbridge Island, WA, United States of America

Gerald T Nepom