Emisphere Technologies, Inc.

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

George Frederick Klein

Yi Ren

Pingsheng Zhang

Joseph Norman Bernadino

William Elliot Bay

William Elliott Bay

Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.

Process for the manufacture of SNAC (salcaprozate sodium)

Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

Methods for producing N-(8-[2-hydroxybenzoyl]-amino) caprylic acid

Growing community of inventors

Tarrytown, NY, United States of America

George Frederick Klein