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Degussa - Huls Ag

Forschungszentrum J&#xdc;lich Gmbh

Degussa Ag, Intellectural Property Management

Degussa Ag, Intellectual Property Management

Georg Thierbach

Brigitte Bathe

Walter Pfefferle

Michael Binder

Natalie Schischka

Caroline Kreutzer

Nicole Dusch

Klaus Huthmacher

Dieter Greissinger

Mechthild Rieping

Alfred Puhler

Bettina Moeckel

Thomas Bekel

Mike Farwick

Hermann Sahm

Thomas Hermann

Lothar Eggeling

Stephan Hans

Frank Schneider

Jorn Kalinowski

Alfred Puehler

Joern Kalinowski

Christine Bastuck

Christian Rueckert

Petra Ziegler

Kornelia Voss

Andreas Tauch

Wilfried Claes

Jörn Kalinowski

Alfred Pühler

Bernhard Eikmanns

Volker F Wendisch

Silke Jerrentrup

Bastian Blombach

Kornelia Voß

Frank Elischweski

Jurgen Dohmen

Daniela Kruse

Verena Engels

Achim Marx

Bettina Mockel

IIona Walger

Michel Eduard Van Der Rest

Douwe Molenaar

Ulrich Becker

Andreas Schaefer

Jennifer Brehme

Hermann Thomas

Michael Buchholz

Kornelia Voβ

Klaus Erich Uffmann

Michaela Voss

Hans J Kutzner

Frank Bachmann

Hans Sonnen

Petra-Sabine Kautz

Fermentative production of L-lysine using an L-lysine excreting bacterium of the specieshaving a completely or partly deleted whiB4 gene is provided.

Method for the fermentative production of L-lysine using an L-lysine excreting bacterium of the specieshaving a completely or partly deleted WHIB4 gene

A bacterium of the specieshas the ability to excrete L-lysine, and contains in its chromosome a polynucleotide encoding a mutated polypeptide having the assumed function of an acyltransferase, hydrolase, alpha/beta hydrolase or of a pimeloyl-ACP methyl ester esterase. Also, a method is used for producing L-lysine using such bacterium.

Method for the fermentative production of L-lysine

A method is useful for the fermentative production of L-lysine using astrain having a mutated Kup transporter.

Method for the fermentative production of L-lysine usingstrains with a mutated kup transporter

A method is used for the fermentative production of L-lysine using bacteria of the species, having the ability to excrete L-lysine and containing in their chromosome a mutated NCgl2816 polynucleotide. Further, the method is used for cultivating the bacteria in a suitable medium under suitable conditions, and accumulating said L-lysine in the suitable medium to form an L-lysine containing fermentation broth.

Method for the fermentative production of L-lysine by modified

The present invention provides a bacterium of the genus, in particular of the species, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.

Method for the fermentative production of L-amino acids

The present invention relates to polynucleotides encoding novel fusion polypeptides essentially composed of a signal peptide for membrane translocation and a polypeptide providing &#x3b1;-1,6-glucosidase activity and to bacteria containing said polynucleotides. The invention further relates to methods for producing fine chemicals using media containing isomaltose and/or panose as carbon source.

Method for the production of fine chemicals using asecreting modified &#x3b1;-1,6-glucosidases

The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.

Alleles of the oxyR gene from coryneform bacteria

The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.

Process for the fermentative preparation of organic chemical compounds using Coryneform bacteria in which the sugR gene is present in attenuated form

The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.

Mutant of the proB gene from coryneform bacteria

The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

Coryneform host-vector systems comprising a chromosomal ALR gene which is attenuated or eliminated and methods of using

An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.

Alleles of the rel gene from coryneform bacteria

The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.

Alleles of the zwf gene from coryneform bacteria

Alleles of the thrA gene from Enterobacteriaceae encoding desensitized aspartokinase I-homoserine dehydrogenase I enzymes and methods for the fermentative production of L-threonine using bacteria containing these alleles.

Alleles of the thrA gene of Enterobacteriaceae

Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form

An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.

Alleles of the PRPD1 gene from coryneform bacteria

Growing community of inventors

Bielefeld, Germany

Georg Thierbach