University of California

Gary W Small

Jorge R Barrio

Nagichettiar Satyamurthy

Sung-Cheng Huang

Gregory M Cole

Andrej Petric

Vladimir Kepe

Koon-Pong Wong

A method of using PET imaging includes using PET images obtained using a radiotracer for the determination of the progressive course of regional brain PET activities for a progressive neurodegenerative disease (e.g., MCI, AD, and CTE). The method may be used for the automatic staging of neurodegenerative disease for a particular patient/subject based on regional intensity and spatial patterns of the brain signals measured by PET imaging. The method may also be used to diagnose or classify the disease of a patient among multiple possibilities based on PET imaging profiles (e.g., for separating or distinguishing CTE from AD).

Method for positron emission tomography (PET) imaging analysis for classifying and diagnosing of neurological diseases

Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled withF,I,I,I, orC. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.

In vivo imaging of sulfotransferases

Compositions useful for labeling &#x3b2;-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I): wherein Ris selected from the group consisting of &#x2014;C(O)-alkyl, &#x2014;C(O)-alkylenyl-R, &#x2014;C(O)O-alkyl, &#x2014;C(O)O-alkylenyl-R, &#x2014;C&#x2550;C(CN)-alkyl, &#x2014;C&#x2550;C(CN)-alkylenyl-R, wherein Ris a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; Ris a radical selected from the group consisting of &#x2014;NH, &#x2014;OH, &#x2014;SH, &#x2014;NH-alkyl, &#x2014;NHR, &#x2014;NH-alkylenyl-R, &#x2014;O-alkyl, &#x2014;O-alkylenyl-R, &#x2014;S-alkyl, and &#x2014;S-alkylenyl-R; Ris a radical selected from the group consisting of &#x2014;CN, &#x2014;COOH, &#x2014;C(O)O-alkyl, &#x2014;C(O)O-alkylenyl-R, &#x2014;C(O)-alkyl, &#x2014;C(O)-alkylenyl-R, &#x2014;C(O)-halogen, &#x2014;C(O)NH-alkyl, &#x2014;C(O)NH-alkylenyl-Rand &#x2014;C(O)NH; Ris a radical selected from the group consisting of O, NH, and S; and Ris N, O or S; and Ris selected from the group consisting of alkyl and alkylenyl-Rand Ris alkylenyl-R, wherein Ris selected from the group consisting of &#x2014;OH, &#x2014;OTs, halogen, spiperone, spiperone ketal, and spiperone-3-yl, or Rand Rtogether form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkyl-R, carbonyl, spiperone, spiperone ketal and spiperone-3-yl, and further wherein one or more of the hydrogen, halogen or carbon atoms are optionally replaced with a radiolabel.

Compositions for labeling &#x3b2;-amyloid plaques and neurofibrillary tangles

Methods for labeling &bgr;-amyloid plaques and neurofibrillary tangles

A method for labeling &bgr;-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I):

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Los Angeles, CA, United States of America

Gary W Small