The General Hospital Corporation

Other

Gary J Brenner

Giulia Fulci

Xandra O Breakefield

Sherif Ahmed

Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.

Methods and compositions relating to the treatment of tumors

Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.

AAV1-caspase gene therapy induced pyroptosis for the treatment of tumors

Methods and associated structures for improving streaming database translation by use of an auxiliary database to store supplemental information derived as a by-product of the importation process and to then update the target database of the importation process using the supplemental information so generated. The supplemental information may include information such as supplemental attributes that define additional joins to be created in the target database following importation. In particular aspects hereof applicable to GIS database applications, supplemental geometric information may be derived from the source database during the importation process and stored in the auxiliary database. Following completion of the importation, the target database may be updated to add the geometric information from the auxiliary database to the newly imported objects in the target database.

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Winchester, MA, United States of America

Gary J Brenner