Centre National De La Recherche Scientifique

Université De Nice Sophia Antipolis

L'université Nice Sophia Antipolis

Université Nice Sophia Antipolis

Ez-Zoubir Amri

Gérard Paul Ailhaud

Christian Dani

Marcel Scheideler

Christian Jean Lucien Dani

Michael Karbiener

Christian Elabd

Gérard Ailhaud

The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bc12 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1 beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.

Established human brown adipocyte line and method for differentiation from an hMADS cell line

The present invention relates to compositions comprising an agent, like a polynucleotide, which induces or upregulates expression of UCP1 for use in treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject. The present invention also relates to a method of treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject comprising administrating a composition comprising a polynucleotide which induces or upregulates expression of UCP1.

UCP1 (thermogenin)&#x2014;inducing agents for use in the treatment of a disorder of the energy homeostasis

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Nice, France

Ez-Zoubir Amri