The Upjohn Co.

Other

Ernest W Yankee

Ronald H Rynbrandt, Deceased

The present invention provides certain 2,3-didehydro-5-oxopyrrolizidinones and indolizidinones which are useful as lipid-altering and anti-atherosclerotic agents.

Pyrrolizidine-3-ones

This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is of the cis configuration. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

.omega.-Aryl-cis-13-PGF compounds

.omega.-Aryl-cis-13-PGE compounds

.omega.-Aryl-cis-13-inter-oxa-PGA compounds

.omega.-Aryl-cis-13-PGA compounds

.omega.-Aryl-cis-13-inter-oxa-PGE compounds

.omega.-Aryl-cis-13-inter-oxa-PGF compounds

Cis-4,5-didehydro-cis-13-PGE.sub.1 , compounds

This invention comprises certain .omega.-aryl-.omega.-polynor analogs of the prostaglandins in which configuration of the 11-hydroxyl is beta. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

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Portage, MI, United States of America

Ernest W Yankee