Spa Societa Prodotti Antibiotici S.p.a.

Solchem Italiana S.p.a.

Ernani Dell'Acqua

Tiberio Bruzzese

Lorenzo Ferrari

Holger H Van Den Heuvel

Eric Arthur Johnson

Rodolfo Ferrari

Franco Ottoni

Giorgio Quaglia

This invention relates to a composition of food having animal and/or vegetable origin which contains lysozyme and a chelating agent in amounts that are effective at preventing contamination of the food by Clostridium botulinum.

Composition active against botulism

Process for the decontamination of vegetable foods from Listeria-sp. which consists in adding solutions of lysozyme, non-toxic and physiologically compatible salts thereof, to said foods, with or without adjuvant substances, at concentrations suitable for affording decontamination.

Process for bacterial decontamination of vegetable foods

A process for the preparation of foods of animal origin wherein efficacious quantities of lysozyme or its non-toxic salts--and optionally of synergic agents or adjuvant--are added to said foods to the purpose of obtaining foods free of Listeria bacteria.

Process for obtaining foods free of Listeria bacteria

The process for the preparation of derivatives of 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide of the formula ##STR1## wherein R represents hydroxy (Ia) or substituted hydroxy OR.sub.1 in which R.sub.1 is the cinnamoyl radical --CO--CH.dbd.CH--C.sub.6 H.sub.5 (Ib) consists in reacting a strong base salt of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with an acyl chloride R.sub.1 Cl, in which R.sub.1 is the cinnamoyl radical, or R.sub.2 Cl, in which R.sub.2 is an aromatic or aliphatic C.sub.2 -C.sub.6 acyl radical to give the corresponding mixed anhydride, optionally esterified at position 4, which is then reacted with 2-aminopyridine to give the desired amide.

Process for preparing

The invention relates to new rifamycins derivatives endowed with antibiotic activity and process for their preparation. The new rifamycins derivatives have the formula: ##STR1##

Rifamycins derivatives and preparation and pharmaceutical compositions

A new benzothiazine derivative, that is N-(2-pyridyl)-2-methyl-4-cinnamoyloxy-2H-1,2-benzothiazine-3-carboxamido 1,1-dioxide has been prepared. Owing to its peculiar ester structure, obtained by condensation with cinnamic acid, the new product is endowed with so outstanding pharmacological and toxicological activities, particularly with reference to its tolerableness, to make it a therapeutically valuable anti-inflammatory drug.

Anti-inflammatory 1,2-benzothiazines

The present invention provides a method of treating domestic animals which are infected or endangered by micro-organisms, as well as solid and liquid nutriments for domestic animals comprising lysozyme and/or at least one non-toxic salt thereof. The present invention also provides, as new compounds, lysozyme phosphate, glycerophosphate, lactate, gluconate and hexametaphosphate, as well as a process for the preparation thereof.

Method of treating domestic animals

The present invention provides a water-soluble pharmaceutical complex, comprising the antibiotic partricin and/or an alkyl ester thereof and sodium desoxycholate and/or sodium dehydrocholate.

Water-soluble pharmaceutical complexes of partricin or an alkyl ester

The present invention provides a water-soluble pharmaceutical composition, comprising partricin and/or partricin methyl ester in admixture with at least one anionic and/or cationic surfactant.

Growing community of inventors

Milan, Italy

Ernani Dell'Acqua