Northwestern University

Eric J Berns

Milan Mrksich

Samuel I Stupp

Horacio Dante Espinosa

Maria D Cebezas

Joshua Goldberger

Prithvijit Mukherjee

Cesar Andres Patino

A cell analysis system includes a multi-layer microfluidic device that includes a layer of microfluidic channels, a layer of microwells, a membrane with nanochannels, and a layer of extraction chambers. The microwells and the membrane are configured to allow culturing of cells that are adhered to the membrane or suspended in the microwells, and the membrane is configured to allow diffusion of substances across the membrane into the layer of extraction chambers. The cell analysis system includes a top conductive layer and a bottom conductive layer on the opposite sides of the multi-layer microfluidic device. The cell analysis system also includes a function generator configured to apply an electroporation pulse between the top conductive layer and the bottom conductive layer.

Microfluidic device for live cell manipulation and analysis

The disclosure provides a cell-based, label-free assay compatible with high-throughput screening (HTS) that can report quantitatively on enzyme activities by measuring mass changes of substrates with MALDI-mass spectrometry.

Cellular assays with a molecular endpoint measured by SAMDI mass spectrometry

The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration.

Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope

Growing community of inventors

Park Ridge, IL, United States of America

Eric J Berns