Rhone-Poulenc Chimie

Other

Rhone-Poulenc Rorer S.a.

Rhone-Poulenc Sante

Adisseo France Sas

Rhone-Poulenc Nutrition Animale

Eraclis Statiotis

Pierre Labourt-Ibarre

Jean-Claude Le Thiesse

Michel Deleuil

Robert Rona

Eric Cervos

Véronique Chiavazza

Jean Brossette

A particulate composition comprising (a) an oil of a vitamin, an oil containing one or more vitamins or a derivative, (b) a gelling agent of vegetable origin having a glass transition point greater than 20&#xb0; C., and (c) a protein, except gelatine.

Particulate vitamin composition

Storage-stable, free-flowing and attrition-resistant, essentially spheroidal solid beads of vanillin and/or ethylvanillin, characteristically prilled from a melt thereof, are useful flavoring/perfuming agents.

Vanillin and/or ethylvanillin solid beads

The present invention relates to a novel presentation of a product exhibiting the phenomenon of supercooling. More precisely, the subject of the invention is cristallized pearls of a product exhibiting strong supercooling. The invention also relates to the preparation of the said pearls. The characteristic feature of the process of the invention is to melt, if necessary, the product to be shaped; to break up the molten mass into droplets; to cool the droplets to a temperature below the glass transition temperature of the product, so that these droplets harden by vitrification; to maintain the pearls thus vitrified at a temperature below the glass transition temperature and to place them in contact with crystallization seeds; to crystallize the pearls by raising the temperature above the glass transition temperature and then to recover the crystallized pearls.

Process for obtaining cristallized pearls exhibiting the phenomenon of

Free-flowing, non-agglomerating and attrition resistant, substantially spherical solid beads/spherules of a coumarin compound, advantageously having a particle size ranging from 100 .mu.m to 2,000 .mu.m, a loose bulk density ranging from 0.25 to 0.8 and a compressive strength ranging from 500 to 10,000 N/m.sup.2, dissolve rapidly in ethanol and are conveniently prepared by prilling/fragmenting a melt of the coumarin compound into a stream of a cooling gas.

Coumarin spherules/beads having unique morphology

An oil-in-water emulsion is passed through a nozzle to form spherules which are allowed to fall countercurrent to a flow of cold air and which are recovered utilizing either a liquid crosslinking agent or a solution, preferably aqueous, optionally containing a crosslinking agent.

Process for the preparation of spherules

Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form with a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

Process for the preparation of medication in the form of pearls

Process for the preparation of pearls based on a pharmaceutical active substance exhibiting an indefinite crystallization point. The said active substance is mixed in molten form which a pharmaceutical excipient promoting the solidification of the active substance, the melt is forced to pass through a nozzle which is subjected to a vibration, the pearls formed are allowed to fall in a tower countercurrentwise to a gas, and the pearls formed are collected in the bottom of the tower.

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Villette d'Anthon, France

Eraclis Statiotis