Sangamo Biosciences, Inc.

Elizabeth J Wolffe

Edward J Rebar

Fyodor Urnov

Stephen P Eisenberg

Eric E Jarvis

Andrew Jamieson

Qiang Liu

Pei-Qi Liu

Albert Lai

Eva Raschke

Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

Regulation of angiogenesis with zinc finger proteins

Methods and compositions for regulating gene expression are provided. In particular, methods and compositions comprising localization domains, and fusions of localization domains with DNA binding domains and, optionally regulatory domains, are provided.

Modulation of gene expression using localization domains

Growing community of inventors

Orinda, CA, United States of America

Elizabeth J Wolffe