Juridical Foundation the Chemo-sero-therapeutic Research Institute

Eiji Tokunaga

Masashi Sakaguchi

Sachio Tokiyoshi

Fukusaburo Hamada

Toshihiro Ushijima

Kazuo Matsuo

Kenji Yokogawa

A variant ofsurface protective antigen SpaA protein or of a shortened form of SpaA (&#x394;SpaA) in which a portion of SpaA protein is deleted for protection frominfection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or &#x394;SpaA protein provides a variant of SpaA or &#x394;SpaA protein which is immunogenic and is expressed inas inclusion bodies. The variant of SpaA or &#x394;SpaA protein of the present invention may easily be recovered and purified since it is expressed inas inclusion bodies.

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A novel peptide obtained fromhas been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The invention further provides a gene coding for the polypeptide, a recombinant vector for expression of this gene, a host transformed with this vector, a process for preparing the polypeptide in a host, a vaccine for avian infectious coryza comprising the polypeptide as an active ingredient, a monoclonal antibody obtained using the polypeptide as an immunogen, and a diagnostic agent and a therapeutic agent for avian infectious coryza using the peptide and the antibody.

Polypeptide for Haemophilus paragallinarum and process for preparing the same

A novel peptide obtained from has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The invention further provides a gene coding for the polypeptide, a recombinant vector for expression of this gene, a host transformed with this vector, a process for preparing the polypeptide in a host, a vaccine for avian infectious coryza comprising the polypeptide as an active ingredient, a monoclonal antibody obtained using the polypeptide as an immunogen, and a diagnostic agent and a therapeutic agent for avian infectious coryza using the peptide and the antibody.

Polypeptide originating in haemophilus paragallinarum and process for producing the same

The preset invention provides a method for immunizing chickens which comprises inoculating into growing egg a composition comprising either cell-free attenuated viruses of Marek's disease type 1 or cells infected with attenuated viruses of Marek's disease type 1 capable of producing cell-free viruses. The present invention also provides a method for immunizing chickens which comprises inoculating into growing egg a mixed vaccine comprising said composition plus another vaccine from at least one microorganisms selected from the group consisting of viruses other than virus of Marek's disease type 1, bacteria and protozoan.

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Kumamoto, Japan

Eiji Tokunaga