Suntory Holdings Limited

Kyoto University

Nisshin Pharma Inc.

Eiji Sakuradani

Jun Ogawa

Misa Ochiai

Akinori Ando

Sakayu Shimizu

Hiroshi Kawashima

Shigeru Hiramoto

Masataka Harata

Yuki Takemoto

Provided is3 desaturase having high enzymatic activity even at normal temperature. A polypeptide which consists of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and has3 desaturation activity on C20 fatty acid, and a gene thereof.

&#x3c9;3 fatty-acid desaturase and method for producing eicosapentaenoic acid

The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus. The present invention provides a polynucleotide which contains any one nucleotide sequence selected from the group consisting of SEQ ID NO: 1 to 28, or a variant thereof.

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The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus. The present invention provides a polynucleotide which contains any one nucleotide sequence selected from the group consisting of SEQ ID NOs: 1 to 28, or a variant thereof.

Promoter exhibiting high expression activity in mortierella microorganisms

The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus. The present invention provides a polynucleotide which contains a nucleotide sequence selected from SEQ ID NOs: 1 to 28, or a variant thereof, as well as a non-human transformant containing such a polynucleotide.

The present invention provides a novel acetyl-CoA carboxylase. The object of the present invention is attained by the nucleotide sequence of SEQ ID NO: 1 and the amino acid sequence of SEQ ID NO: 2 of the present invention.

Acetyl-CoA carboxylase

The present invention provides a polypeptide having a wide substrate specificity and having a &#x3c9;3 fatty acid desaturation activity, which makes efficiently unsaturated bond at &#x3c9;3 position, and a polynucleotide coding for the same. By expressing the polypeptide in the organism, mass production of n-3 series PUFAs is enabled. Specifically, the polypeptide having a &#x3c9;3 fatty acid desaturation activity and consisting of the amino acid sequence represented by SEQ ID NO: 1, a polynucleotide coding for a polypeptide having a &#x3c9;3 fatty acid desaturation activity that consists of the base sequence represented by SEQ ID NO: 2 or SEQ ID NO: 3, and the like is useful for production of n-3 series fatty acids.

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Kyoto, Japan

Eiji Sakuradani