Scripps Clinic and Research Foundation

Rorer Biotechnology Inc.

Enzon Labs Inc.

Dorothea H Scandella

William N Drohan

Theodore S Zimmerman

Carol A Fulcher

Keith H McKenney

This invention is directed to a novel hybrid regulatory region for directing and regulating transcription and translation of a gene sequence positioned downstream from the hybrid regulatory region. This hybrid regulatory region includes the promoter sequence of the phage lambda P.sub.R promoter-operator region fused to the operator sequence of the phage lambda P.sub.L promoter-operator region.

Hybrid gene regulatory region operable in E. coli

New fragments of the Factor VIII procoagulant protein (Factor VIIIC) are disclosed. These fragments have an Mr value of 88,000 d or 49,000 d or extend from amino acid residues 1974 to 2332 or 2052 to 2332. These fragments have use in the treatment of patients who have developed antibodies which inhibit Factor VIII.

Recombinant Factor VIIIC fragments

Recombinant factor VIIIC derived fragments

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Gaithersburg, MD, United States of America

Dorothea H Scandella