Johns Hopkins University

Donald William Parsons

Bert Vogelstein

Kenneth W Kinzler

Nickolas Papadopoulos

Victor E Velculescu

Sian Jones

Ralph Hruban

Scott E Kern

Alberto Bardelli

Rebecca J Leary

Yardena Samuels

Xiaosong Zhang

Giovanni Parmigiani

Michael Goggins

Rachel Karchin

Tian-li Wang

James R Eshleman

Alison Klein

Christopher Lengauer

Philipp Angenendt

Jimmy Chang-Ho Lin

Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.

P13K pathway mutations in cancer

Growing community of inventors

Ellicott City, MD, United States of America

Donald William Parsons