The United States of America as Represented by the Secretary of

United States of America, as Represented by the Secretary of Agriculture

Donald E Corrier

John R DeLoach

David J Nisbet

Larry H Stanker

James A Byrd, Ii

Arthur Hinton, Jr

The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in poultry populations. The incidence of the colonization of poultry by enteropathogenic bacteria, and/or the populations of enteropathogenic bacteria within colonized poultry, may by substantially reduced by providing particles of an expanded matrix material to the locus or vicinity of the animals, particularly during the period of feed removal prior to slaughter. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic and Campylobacter species.

System for the control of enteropathogenic bacteria in the crops of poultry

The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in poultry populations. The incidence of the colonization of poultry by enteropathogenic bacteria, and/or the populations of enteropathogenic bacteria within colonized poultry, may by substantially reduced by providing particles of an expanded matrix material to the locus or vicinity of the animals, particularly during the period of feed removal prior to slaughter. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic,and Campylobacter species.

A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of swine is disclosed. The probiotic includes populations or cultures of substantially biologically pure bacteria which include:

Competitive exclusion culture for swine

A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of substantially biologically pure bacteria, which bacteria include:

Probiotic for control of Salmonella in fowl produced by continuous

A defined probiotic or composition of anaerobic bacteria effective for controlling or inhibiting Salmonella colonization of fowl. The probiotic includes populations or cultures of 29 substantially biologically pure bacteria. In use, the probiotic is administered to the subject fowl in an amount effective for increasing resistance to Salmonella colonization thereof. The invention also relates to a novel method for isolating probiotics which are effective for controlling or inhibiting Salmonella colonization of domestic animals, from fecal droppings, cecal contents or large intestines of the adult animals. The droppings, cecal contents or large intestine are combined with a culture medium and incubated without dilution (i.e. batch culture) under anaerobic conditions. Following this preliminary incubation, the resultant culture is subjected to continuous flow conditions until a steady state is achieved, after which time the steady state culture may be recovered for use as a probiotic.

Probiotic for control of salmonella

Salmonella colonization of fowl may be effectively controlled or inhibited using a defined composition of anaerobic bacteria (i.e., probiotic). the probiotic includes a first culture of substantially pure anaerobic bacteria effective for fermenting lactic acid to produce volatile organic acids including acetic, propionic and/or butyric acids. A second culture of at least one anaerobic bacteria effective for fermenting carbonhydrates to produce lactic acid is also employed in combination with the above-mentioned first cuture. Suitable organisms for use in this first culture include bacteria of the genera Veillonella, Megasphaera, and mixtures thereof. These first and second cultures are administered to the subject fowl in amounts effective for inhibiting Salmonella colonization thereof. In one embodiment, the above-mentioned probiotic may be combined with a conventional feed, providing a novel feed product which may be orally ingested by the fowl.

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College Station, TX, United States of America

Donald E Corrier