Lonza Ag

Lonza Inc.

Corning Incorporated

Noramco Gmbh

Dominique Roberge

Nikolaus H Bieler

Bertin Zimmermann

Rainald Forbert

Michael Gottsponer

Markus Eyholzer

Wilhelm Quittmann

Olivier Lobet

Pierre Woehl

Ulrich Weigl

Celine Claude Guermeur

Laurent Ducry

Maxime Moreno

Fabio Rainone

Christian Schnider

Dario Veghini

Douglas Phillip Cox

Andreas Klein

Stefan Tille

Ulrich Kampfen

Arturo Macchi

Anna-Christina Hormes

Philippe J Barthe

Thomas Gruetzner

Michael Bittel

Petteri Elsner

Janine Leiggener

Christian Oliver Kappe

Norbert Kockmann

Bernhard Gutmann

Michael Amrhein

Yves Glatz

Jared Randall

Patrick Plouffe

The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.

N-demethylation of morphinan alkaloids

A method for preventing plugging of a continuous-reaction channel-system caused by a by-product of a continuous-reaction being carried out in said channel-system comprises the step of generating at least one ultrasonic wave travelling through said channel-system by coupling in a flow direction of at least one process fluid of a plurality of process fluids said at least one ultrasonic wave into said at least one process fluid.

Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method

A micro-reactor system assembly comprises a stack of at least n process modules (-), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (A,B,A,A,A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules () made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (A,A) for accommodating and guiding a heat exchange fluid, wherein each process module (-) is sandwiched between two adjacent heat exchange modules ().

Micro-reactor system assembly

The invention relates to a method for the preparation of imidodisulfuryl compounds in a continuous reaction at elevated temperatures.

Method for preparation of imidodisulfuryl compounds

A method of manufacturing a target reactor having a flow-channel system in which a plurality of reactants continuously flowing into said target reactor are mixed and interconvert to form a target volumetric flow-rate (f) of a product continuously flowing out of said target reactor, wherein the smallest hydraulic diameter (d) of said target reactor is calculated based on the relationship 

Method of manufacturing a reactor and set of reactors

A microreaction device or system () includes at least one thermal control fluidic passage (C,E) and a principal working fluidic passage (A) with average cross-sectional area in the range of 0.25 to 100 mm, and having a primary entrance () and multiple secondary entrances () with the spacing between secondary entrances () having a length along the passage (A) of at least two times the root of the average cross-sectional area of the passage (A). The device or system () also includes at least one secondary working fluidic passage (B) having an entrance () and multiple exits () including a final exit (), each exit () being in fluid communication with a corresponding one of the multiple secondary entrances () of the principal fluidic passage (A).

High throughput thermally tempered microreactor devices and methods

A dosage system for feeding a fluid (A) to a static mixer (), said system comprising a tank () containing said fluid (A) at a predetermined pressure, a fluid passage () connecting said container () and tank (), a control valve () provided within said fluid passage () to control the flow of said fluid (A) from said tank into said container; and a controller () for receiving a target flow rate (SP_Q) of said fluid (A), and an actual flow rate (PV_Q) of said fluid (A), and for outputting a control signal (MV_L) to said control valve () indicating a valve position to adjust the flow rate. Further provided is a method for controlling said dosage system.

Mass flow rate control system

The present invention relates to a process for lithium exchange reactions comprising mixing at least two fluids in a microreactor having at least two injection points.

Method for lithium exchange reactions

The present invention relates to a process for Grignard type reactions comprising mixing at least two fluids in a microreactor having at least two injection points.

Method for grignard type reactions in microreactors

Micro-reactor system

N-Aryl or N-heteroarylformamides are prepared by hydrogenating a corresponding nitroarene or nitroheteroarene with formic acid and/or ammonium formate as hydrogen donor and formylating agent in the presence of at least one noble metal-based hydrogenation catalyst and a vanadium or molybdenum compound as co-catalyst.

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Growing community of inventors

Sierre, Switzerland

Dominique Roberge