The Secant Group, LLC

Cdi Energy Products, Inc.

Dennis Shull

Peter D Gabriele

Jeremy J Harris

Charles Brendan Nicholson

Stephanie M Reed

Carissa Smoot

Todd Crumbling

Jared Ely

John D'Ottavio

Fred B Pippert

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

Tunable, controlled-release, urethane-containing elastomers and processes of forming the same

Compositions and methods are beneficial for use in downhole applications, especially oil and gas well bores. A composition includes an elastomer doped with a dopant. The presence of the dopant increases a rate of microbial degradation of the elastomer by a microbe. A method includes forming an article including a doped polymer. The doped polymer includes an elastomer doped with a dopant. The method also includes placing the article in a service environment. The presence of the dopant in the doped polymer increases a rate of microbial degradation of the elastomer by a microbe in the service environment.

Doped biodegradable elastomer for downhole applications

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Phoenixville, PA, United States of America

Dennis Shull