Irm LLC

Novartis Ag

Deborah A Knee

Quinn L Deveraux

Marc Nasoff

Klaus Wagner

Pedro Aza-Blanc

Jennifer Brogdon

Glenn Dranoff

Fei Wang

Daniela Cipolletta

Garret M Hampton

Garrett M Hampton

The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.

Compositions and methods of use for augmented immune response and cancer therapy

Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.

Methods and compositions for inducing apoptosis in cancer cells with an anti-DR5 antibody

Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.

Methods and compositions for inducing apoptosis in cancer cells

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Del Mar, CA, United States of America

Deborah A Knee