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Matrix Laboratories Limited

Debashish Datta

Ramakoteswara Rao Jetti

Arabinda Sahu

Aggi Ramireddy Bommareddy

Siva Rama Prasad Vellanki

Chetan Kanaiyalal Raval

Lakshmana Rao Vadali

Srikanth Sarat Chandra Gorantla

Raja Babu Balusu

Nagaraju Mittapelly

Srinivasa Rao Dasari

Mofazzal Husain

Nageswara Rao Karusala

Saswata Lahiri

Swapna Thorpunuri

Shankar Rama

Seshadri Rao Manukonda

Mastan Rao Ravi

Veera Narayana Bandlamudi

Hari Babu Nandipati

Aravind Kumar Katukuri

Vikram Vanama

Satishbabu Kothari

Venkata Suryanarayana Ponnekanti

Uma Sankara Sastry Tummalapally

Srikanth G S C

Appi Reddy Talatala

Ravindrababu Kilaru

Swamy Saidugari

Sivaram Prasad Vellanki

Verra Narayana Bandlamudi

Parameshwar Makam

Ankama Nayudu Annadasu

Siva Rama Vellanki

Ramireddy Bommareddy Aggi

Venkata Srimannarayana Deevi

Naveen Kumar Phaduri

Rajababu Balusu

The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-Imorpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R, S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the compound (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one with hydroxy protecting group b) hydrolyzing the obtained compound c) condensing with a chiral auxiliary d) reacting with an protected imine compound e) converting to alkyl ester f) cyclizing and g) deprotecting to obtain Ezetimibe.

Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe

The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form &#x3b3; and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form &#x3b3; with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.

Polymorphic forms of perindopril (L)-arginine and process for the preparation thereof

The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.

Process for the preparation of tenofovir disoproxil fumarate

A process for the preparation of Darunavir comprises the reacting of 4-amino-N-(2R, 3S) (3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide with (3R, 3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol derivative in N-methyl-2-pyrrolidinone and isolating the resulting Darunavir. The process yields Darunavir with a very low level of the difuranyl impurity.

Process for the preparation of darunavir

The present invention relates to an improved process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of &#x3b1;-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine. 

Process for the preparation of oxcarbazepine

Disclosed herein are novel compounds which are useful as intermediates for producing substituted sulfoxide compounds and a process for producing the same. Further disclosed is a process for producing the substituted sulfoxide compounds used as pharmacologically active agents, employing the novel intermediates of the present invention.

Compounds for producing substituted sulfoxides, process for producing the same and use thereof

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Hyderabad Telangana, India

Debashish Datta