Ribozyme Pharmaceuticals, Incorporated

Sirna Therapeutics, Inc.

Biomics Biotechnologies, Co., Ltd.

Cui, Kunyuan

Sweedler, David

Liang, Dong

David Sweedler

Leonid Beigelman

Alexander Karpeisky

Jasenka Matulic-Adamic

Nassim Usman

Peter Haeberli

Alex B Burgin

Amber Beaudry

Francine E Wincott

Lech W Dudycz

Susan Grimm

Danuta Tracz

Anthony DiRenzo

Shawn Patrick Zinnen

Mark Reynolds

John Min

Alex Karpeisky

Vladimir Serebryany

Nilabh Chaudhary

Kunyuan Cui

Dong Liang

Vladmir Serebryany

Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.

Long interfering nucleic acid duplexes targeting multiple RNA targets

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

Compositions for the delivery of negatively charged molecules

Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.

Synthesis, deprotection, analysis and purification of RNA and ribozymes

Process for chemical synthesis of methoxy nucleosides.

Chemical synthesis of methoxy nucleosides

The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2&prime;-amino, 2&prime;-N-phthaloyl, 2&prime;-O-methyl, 2&prime;-O-silyl, 2&prime;-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives

Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.

Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.

Oligoribonucleotides with enzymatic activity

Synthetic ribonucleic acids with RNAse activity

Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.

Nucleoside triphosphates and their incorporation into oligonucleotides

Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.

Synthesis, deprotection, analysis and purification for RNA and ribozymes

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.

Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed.

Growing community of inventors

Louisville, CO, United States of America

David Sweedler