Johns Hopkins University

Other

David S Bredt

Solomon H Snyder

Ted M Dawson

Valina L Dawson

Arthur L Burnett

Edythe D London

Charles J Lowenstein

Thomas S Chang

Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.

Treatments for male sexual dysfunction

A method of purifying calmodulin-dependent nitric oxide synthase provides a homogeneous preparation of the enzyme. The enzyme is used to raise antibodies which are a useful immunohistochemical reagent. The antibodies localize calmodulin-dependent nitric oxide synthase to a number of anatomical sites, including retina, intestine, adrenal gland, and vasculature. However, activated macrophages, which are known to possess a nitric oxide producing activity, do not display an immunoreactive protein of appropriate size on Western blots using the antibodies. Nucleotide sequences encoding calmodulin-dependent nitric oxide synthase indicate a novel sequence with a flavin binding site consensus sequence.

Purification and molecular cloning of nitric oxide synthase

Inhibitors of nitric acid synthase can be used to prevent neurotoxicity mediated through glutamate receptors. Nitric oxide synthase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease and Huntington's disease.

Inhibitors of nitric oxide synthase and use thereof to prevent glutamate

Growing community of inventors

Baltimore, MD, United States of America

David S Bredt