The United States of America, As Represented by the Secretary, Department of Health and Human Services

David L Narum

Kim Lee Sim

B Kim Lee Sim

Hong Liang

Steve Fuhrmann

Compositions that inhibit the binding ofto erythrocytes include a family of erythrocyte binding proteins (EBPs). The EBPs are paralogues of thebinding protein EBA-175. The present invention includes peptides of the paralogues that prevent the binding of. Antibodies specific for each paralogue that also prevent the binding ofare also included. Methods of the invention utilize the paralogues, antibodies thereof and peptide compositions for the diagnosis, prevention, and treatment ofdiseases such as malaria, as well as methods for the detection ofin biological samples and culture media.

Anti-plasmodium compositions and methods of use

Synthetic gene sequences encoding erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequences are useful for incorporation into the DNA vaccine vectors, for the incorporation into various expression vectors for production of malaria proteins, or both. The synthetic genes may be modified to avoid post-translational modification of the encoded protein in hosts. Administration of the synthetic gene sequences, or the encoded protein, as an immunization agent is useful for induction of immunity against malaria, treatment of malaria, or both.

Synthetic genes for malarial proteins and methods of use

Compositions that inhibit the binding ofto erythrocytes are provided. More particularly, antibodies specific forbinding proteins and blocking peptides that prevent the binding ofare included in the present invention. The methods provided utilize the antibody and peptide compositions provided herein and include methods for the diagnosis, prevention, and treatment ofdiseases such as malaria as well as methods for the detection ofin biological samples and culture media.

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Gaithersburg, MD, United States of America

David L Narum