Senomyx, Inc.

Firmenich Incorporated

Other

Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Daniel Harry Rogers

David Mark Wallace

Xiaodong Li

Mark Zoller

Catherine Tachdjian

Guy Servant

Vincent Darmohusodo

Qing Chen

Andrew P Patron

Xiao-Qing Tang

Farid Bakir

Sara L Adamski-Werner

Marketa Rinnova

Amy Xing

Ming Qi

Stephen Terrence Hobson

Klaus Gubernator

John Patrick Williams

Roger Astbury Smith

Hanno Wild

Long Mao

Jill E Wood

John E Lyons

Robert B Dally

Wendy Lee

Daisy Joe Du Bois

Michael B Katz

Yolanda V Caringal

Cheri Lynn Blum

John Saunders

Ming Cai Lun Lu Qi

The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the 'umami' taste of monosodium glutamate) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the 'umami' taste of monosodium glutamate) or sweet taste modifiers,&#x2014;savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the 'umami' taste of monosodium glutamate) or sweet taste modifiers, &#x2014;savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Compounds of Formula (I):wherein Aris aryl; Aris hydrogen, cycloalkyl, aryl or heteroaryl; Z is &#x2014;C(&#x2550;O) or a single bond; R, R, R, Rand Rare independently hydrogen or alkyl optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon atoms; X is &#x2014;O&#x2014;, &#x2014;NR(where Ris hydrogen or alkyl), (CRR)(where Rand Rare independently in each occurrence hydrogen or alkyl and m is an integer from 0 to 3), or &#x2014;S(O)(wherein n is an integer from 0 to 2); or prodrugs thereof, and pharmaceutically acceptable salts thereof,are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.

2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

Inhibition of raf kinase activity using aryl ureas

This invention relates to certain 3-aminomethylpyrrolidine derivatives of Formula (I): ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Pyrrolidine derivatives-CCR-3 receptor antagonists

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San Diego, CA, United States of America

Daniel Harry Rogers