Princeton University

Colleen T O'Loughlin

Bonnie L Bassler

Scott Michael Ulrich

Lee R Swem

Martin F Semmelhack

Knut Drescher

Albert Siryaporn

Laura C Conrad-Miller

Antivirulence strategies to combat, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the twoquorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

Molecules and compositions that inhibit gram negative bacteria and their uses

A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryotefrom quorum-sensing-mediated killing by the bacterial pathogen. The saving ofdemonstrates the use of these molecules as small molecule antimicrobials.

Small molecule antagonists of bacterial quorum-sensing receptors

Growing community of inventors

Princeton, NJ, United States of America

Colleen T O'Loughlin