Dsm IP Assets B.v.

Nestec S.a.

Boehringer Mannheim Gmbh

Claus Kilpert

Christof Wehrli

Regina Goralczyk

Ann Fowler

Daniel Raederstorff

Joseph Schwager

Goede Schueler

Antoine De Saizieu

Ying Wang-Schmidt

Hasan Mohajeri

Karin Wertz

Edgar Voss

Hubert Hug

Reinhold Carle

Antione De Saizieu

Judith Kammerer

Bettina Boehlendorf

Rudolf Reiter

Nathalie Richard

Bernd Mussler

Annis Olivia Mayne-Mechan

The present invention relates to an improved process for the preparation of an extract enriched in dihydrochalcones, and more specifically enriched in phlorizin, starting from a dry polyphenolic fraction originating from industrial apple processing. The invention also relates to a dihydrochal-cone extract obtainable by this process, and to a food or a nutraceutical product comprising a dihydrochalcone extract of the present invention.

Dihydrochalcone purification process

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether to form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivatives and their uses

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses

The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses

Bishispidine compounds, processes for their production and

Growing community of inventors

Mannheim, Germany

Claus Kilpert