Harvard College

Claudia Kleinlein

Theodore Alexander Betley

Yuyang Dong

Alexandre Mikhailine

Yunjung Baek

Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.

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Cambridge, MA, United States of America

Claudia Kleinlein