Canada Packers Inc.

Slemon, Clarke E.

Bharucha, Kekhusroo R.

Clarke E Slemon

Kekhusroo R Bharucha

Heinrich Maria Schrenk

A process for electrochemically reducing 7-ketolithocholic acid to ursodeoxycholic acid is disclosed. The process may be conducted alone or in conjunction with a simultaneous electrochemical oxidation of chenodeoxycholic acid to 7-ketolithocholic acid. Solvents for the electrochemical reaction which promote stereoselectivity to ursodeoxycholic acid are also disclosed.

Process for the electrochemical reduction of 7-ketolithocholic acid to

A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-aminopenicillanic acid with D(-)-.alpha.-phenylglycylchloride hydrochloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are adjusted to provide good yields of a product of high purity.

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Toronto, Canada

Clarke E Slemon