Genomatica, Inc.

Reg Life Sciences, LLC

Cindy Chang

Andreas W Schirmer

Baolong Zhu

Zhihao Hu

Behnaz Behrouzian

Donald Eugene Trimbur

Stephen B Del Cardayre

Louis G Hom

Haibo Wang

Derek L Greenfield

Emanuela E Popova

Jessica Winger

The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

Methods of producing omega-hydroxylated fatty acid derivatives

The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

Omega-hydroxylase-related fusion polypeptides with improved properties

The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

Acetyl-CoA carboxylase variants

Growing community of inventors

South San Francisco, CA, United States of America

Cindy Chang