Abbott Laboratories Corporation

Chron-Si Lai

Keith A Garleb

Bryan W Wolf

John B Lasekan

Matthew A Kuchan

Bruce B Blidner

Steven R Davis

Christopher T Cordle

Timothy W Schenz

Gary E Katz

Russell J Merritt

Jomay Chow

Jacqueline Boff

Joseph E Walton

Paul W Johns

Tapas Das

Mustafa Vurma

Kati E Shearer

Charles Helmke

Charles R Helmke

Christopher T Cordel

Christopher Cordle

James Wen-Liu

Kati Draper

Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

Nutritional compositions comprising hydrolyzed protein and a modified fat system and uses thereof

Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system development in an individual. The nutritional compositions include a combination of RRR-alpha tocopherol acetate, non-RRR-alpha-tocopherol stereoisomers, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited.

Method of using a composition for enhancing newborn infant cognitive, brain and/or CNS development

This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.

Infant nutritional product with RRR alpha-tocopherol

Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

Method of improving visual processing, visual acuity, or both by administering compositions comprising RRR-alpha-tocopherol to infants

Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

Method of improving visual processing, visual acuity, or both by administering compositions comprising RRR-alpha-tocopherol and carotenoid to infants

Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited. Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.

Composition for enhancing newborn infant cognitive, brain and/or CNS development and method of using same

Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.

Nutritional products including a novel fat system including fatty acids

Methods for improving tolerance, digestion, and lipid soluble nutrient absorption in an infant, toddler, or child

Methods of improving tolerance related to feeding in an infant, toddler, or child

Nutritional products including a novel fat system including monoglycerides

Nutritional products including monoglycerides and fatty acids

Methods for decreasing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome in an infant, toddler, or child

Disclosed is a method of making nutritional emulsions, comprising: (A) heating and blending together an emulsifying agent having a melt point above about 25 C and oil having hydrophobic off-notes (e.g. non-encapsulated polyunsaturated fatty acid) in a weight ratio of at least about 1:15; (B) adding the heated blend to a fat, protein, and carbohydrate mixture comprising a maltodextrin (DE of about 10 or less), in a weight ratio of the maltodextrin to the oil having hydrophobic off-notes of at least about 1:2; and (C) homogenizing, and then cooling the combination below the melt point of the emulsifying agent to form a nutritional emulsion comprising from about 0.01% to about 5% by weight of process-encapsulated polyunsaturated fatty acid. The resulting nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.

Method of making nutritional emulsions containing process-encapsulated oils

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Blacklick, OH, United States of America

Chron-Si Lai