Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Universitè De Montpellier

Academisch Medisch Centrum

Centre Hospitalier Universitaire De Montpellier

Centre Hospitalier Régional Universitaire De Montpellier

Txcell

Ecole Nationale Superieure De Chimie De Montpellier (enscm)

Université De Montpellier I

Christian Jorgensen

Jean Martinez

Arnaud Foussat

Valérie Brun

Guillaume Laconde

Muriel Amblard-Caussil

Florence Apparailly-Sechan

Isabelle Duroux-Richard

Paul Peter Tak

Nathalie Belmonte

Valerie Brun

Helene Asnagli

Hélène Asnagli

The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an a-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.

Stapled peptides and uses thereof

The present invention relates to the field of adeno-associated virus (AAV) based gene therapy, in particular in vivo gene therapy, of rheumatoid arthritis (RA). The invention provides recombinant AAV virions being highly efficient in delivering genes encoding therapeutic proteins to the arthritic joints, and method for using such virions in in vivo gene therapy.

AAV vectors for in vivo gene therapy of rheumatoid arthritis

Growing community of inventors

Lattes, France

Christian Jorgensen