Chung Yuan Christian University

Mackay Memorial Hospital

Cheng-An J Lin

Cheng-Yi Huang

Walter Hong-Shong Chang

Tzu-Yin Hou

Chih-Hsien Lee

Walter H Chang

Hung-I Yeh

Yeeu-Chang Lee

Hsueh-Hsiao Wang

Chia-Hui Lin

Yuh-Show Tsai

Ming-Chen Wang

Wen-Kai Chuang

You-Wei Li

Chi-An Chen

Chih-Kuang Yeh

Cherng-Jyh Ke

Yi-Tang Sun

Ching-Yun Chen

Disclosed herein are device and method for performing a total internal reflection scattering (TIRS) measurement to a sample slide. The device comprises a first reflective plate having a first opening; a second reflective plate having second and third openings and disposed on top of the first reflective plate thereby forming a slot therebetween for accommodating the sample slide, wherein the first opening of the first reflective plate is disposed directly underneath the second opening of the second reflective plate; a white light source disposed in the space formed by the third opening of the second reflective plate and configured to emit a white light into the slot; and a first blackout layer disposed on top of the third opening thereby covering the white light source and keeping the emitted white light from leaking. When the sample slide is inserted into the slot, the white light source illuminates the sample slide so as to achieve the TIRS measurement to the sample slide.

Device and method for performing total internal reflection scattering measurement

Disclosed herein are composite fluorescent gold nanoclusters with high quantum yield, as well as methods for manufacturing the same. According to some embodiments, the composite fluorescent gold nanocluster includes a gold nanocluster and a capping layer that encapsulates at least a portion of the outer surface of the gold nanocluster. The capping layer includes a matrix made of a benzene-based compound, and multiple phosphine-based compounds distributed across the matrix.

Composite fluorescent gold nanoclusters with high quantum yield and method for manufacturing the same

Disclosed herein are a light-emitting diode (LED) package structure and a method producing the same. The LED package structure includes a substrate; and a light-emitting unit disposed on the substrate. The light-emitting unit comprises a gallium nitride-based semiconductor, and a polymeric layer encapsulating the gallium nitride-based semiconductor. Also disclosed herein is a method of producing the LED package structure. The method comprises: providing a substrate; electrically connecting a gallium nitride-based semiconductor onto the substrate; overlaying the gallium nitride-based semiconductor with a slurry comprising a resin and a plurality of composite fluorescent gold nanocluster; and curing the slurry overlaid on the gallium nitride-based semiconductor to form a solidified polymeric layer.

Light-emitting diode package structure and method for manufacturing the same

A medical contrast agent made of microbubbles containing Au nanoclusters is provided. The shell of the microbubbles contains fluorescent Au nanocluster-albumin complex, and the core contains air or fluorocarbons. The method for preparing the microbubbles is also disclosed.

Medical contrast agent made of microbubbles containing fluorescent gold nanoclusters

Disclosed herein is the novel use of a gold nanocluser for ameliorating oxidative stress and/or aging of a cultured cell or a subject having an oxidative stress and/or aging condition mediated by a vascular factor. The gold nanocluster has a particle size ranging from about 0.1 to 20 nm, and preferably is dihydrolipoic acid (DHLA) coated gold nanocluster.

Use of gold nanoclusters in ameliorating oxidate stress and/or aging

The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.

Method for forming nano-bubble

The present invention discloses a tunable fluorescent gold nanocluster. The tunable fluorescent gold nanocluster is formed by mixing gold trichloride (AuCl) with toluene solvent without reductant. The tunable fluorescent gold nanocluster emits blue fluorescence that can be red shifted through ultrasonic vibration. The spectral region of the tunable fluorescent gold nanocluster is from 400 nm to 550 nm.

Tunable fluorescent gold nanocluster and method for forming the same

Growing community of inventors

Taoyuan County, Taiwan

Cheng-An J Lin