Korea University Research and Business Foundation

Sfc Co., Ltd.

Chang Su Lim

Eun Sun Kim

Bong-Rae Cho

Hoon Jai Chun

Ji Yeon Kim

Sajal Kumar Das

Sun Young Yang

Dong Eun Kang

The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 &#x3bc;m in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm.

Two-photon probe for detecting copper(II) ion and quantitative estimation of copper(II) ion in human tissue using the same

The present disclosure relates to a two-photon fluorescent dye for imaging total sulfide in vivo and a method for quantitatively estimating total sulfide concentration in vivo using the same. The two-photon fluorescent dye, which includes a compound of [Chemical Formula 1], can detect hydrosulfide ion and image total sulfide and allows quantitative estimation of total sulfide concentration in vivo.

Two-photon fluorescent probes for imaging of total sulfide in live cell and tissue, and quantitative estimation of total sulfide concentration using the same

Growing community of inventors

Seoul, South Korea

Chang Su Lim