Gilead Sciences, Inc.

Nexstar Pharmaceuticals, Inc.

Brian James Hicke

Larry M Gold

David H Parma

Philippe Bridonneau

Stephen L Warren

Donald S Coffey

Shawn E Lupold

Yun Lin

This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.

High affinity nucleic acid ligands to lectins

Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.

Tenascin-C nucleic acid ligands

Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ligands to PSMA, and methods and compositions for the treatment and diagnosis of disease using the nucleic acid ligands.

Nucleic acid ligands to the prostate specific membrane antigen

This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.

Growing community of inventors

Boulder, CO, United States of America

Brian James Hicke