University of Louisville Research Foundation, Inc

Advanced Cancer Therapeutics, LLC

Brian F Clem

John Olaf Trent

Sucheta Telang

Jason Chesney

Pooran Chand

Gilles Hugues Tapolsky

Jason B Meier

Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound. 

Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics

Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided.

Small molecule choline kinase inhibitors, screening assays, and methods for treatment of neoplastic disorders

A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.

Family of PFKFB3 inhibitors with anti-neoplastic activities

A methods and compounds for inhibiting 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.

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Louisville, KY, United States of America

Brian F Clem