Duke University

Case Western Reserve University

Brian E Applegate

Joseph A Izatt

Changhuei Yang

Andrew M Rollins

Michael Choma

Siavash Yazdanfar

Marinko Sarunic

Divakar K Rao

Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor. A full-range depth image of the object is then generated using the full-range depth profile.

Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography

Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.

Method for optical coherence tomography imaging with molecular contrast

Growing community of inventors

Durham, NC, United States of America

Brian E Applegate