Fonterra Co-Operative Group Limited

Societe Des Produits Nestle S.a.

Bing Wang

Bertram Yin Fong

Geoffrey Stevens

Alan David Welman

Christopher Paul McJarrow

Zhizhong Dong

Yujie Shi

A method of producing sialyloligosaccharides a sialyloligosaccharides-containing source that also contains carbohydrates and minerals. The process includes subjecting the source to a temperature of from about 67° C. and (i) filtration with a heat-resistant filter at a temperature of about 35 to about 95° C. to produce a first retentate and first permeate, or (ii) centrifugal separation to produce a light phase and a heavy phase and filtration of the light phase at a temperature of about 50 to about 70° C. to produce a first retentate and first permeate, (b) nanofiltration of the first permeate, or nanofiltration and diafiltration of the first permeate, to produce a second retentate and second permeate, and (c) concentration of the second retentate, to produce a sialyloligosaccharide-containing extract. Additionally, the invention relates to a sialyloligosaccharide-enriched composition comprising at least 3'-sialyllactose and 6′-sialyllactose and its use in, for example, nutritional and infant formulas, and for maintaining or improving cognitive function.

Dairy product and process

This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3'-Siallylactose (3&#x2032;-SL) and 6&#x2032;-Siallylactose (6&#x2032;-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

Composition comprising Siallylactose for use in enhancing learning skills and memory function

A method of producing sialyloligosaccharides a sialyloligosaccharides-containing source that also contains carbohydrates and minerals. The process includes subjecting the source to a temperature of from about 67&#xb0; C. and (i) filtration with a heat-resistant filter at a temperature of about 35 to about 95&#xb0; C. to produce a first retentate and first permeate, or (ii) centrifugal separation to produce a light phase and a heavy phase and filtration of the light phase at a temperature of about 50 to about 70&#xb0; C. to produce a first retentate and first permeate, (b) nanofiltration of the first permeate, or nanofiltration and diafiltration of the first permeate, to produce a second retentate and second permeate, and (c) concentration of the second retentate, to produce a sialyloligosaccharide-containing extract. Additionally, the invention relates to a sialyloligosaccharide-enriched composition comprising at least 3'-sialyllactose and 6&#x2032;-sialyllactose and its use in, for example, nutritional and infant formulas, and for maintaining or improving cognitive function.

Growing community of inventors

New South Wales, Australia

Bing Wang