Indiana University

Binbin Kou

Richard Dennis DiMarchi

Shujiang Cheng

John Philip Mayer

Fa Zhang

Richard D Dimarchi

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Lipidated amide-based insulin prodrugs

Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Amide based glucagon and superfamily peptide prodrugs

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Amide-based insulin prodrugs

Amide based glucagon superfamily peptide prodrugs

Amide based insulin prodrugs

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Bloomington, IN, United States of America

Binbin Kou