Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Ofek Eshkolot Research and Development Ltd

Betty Schwartz

Oded Shoseyov

Patricia Smirnoff

Levava Roiz

Sigal Baruch-Sharon

Roni Almon

Lilach Iasur Kruh

Lili Nimri

Alaa Naama-Amar

Einav Yehuda-Shnaidman

Levav Roiz

The present invention relates to edible plant parts or tissues comprising probiotic bacteria and use thereof for oral delivery of the probiotic bacteria to an organism and enriching and/or improving the organism gastrointestinal tract microbiome. The present invention further relates to methods for selecting and/or producing probiotic bacteria capable of colonizing a plant tissue.

Edible plant parts enriched with probiotic bacteria

Disclosed are methods for treating, preventing and alleviating obesity, fatty liver syndrome, diabetes, one or more metabolic syndrome conditions or complications and/or cancer comprising administering an effective amount of ostreolysin, its functionally related variant, or an extract or mushroom extract comprising the same to subjects in need thereof.

Method of treating a liver disease comprising administering ostreolysin orfunctionally related variant thereof

Method of treating overweight or obesity comprising administering a pleurotus ostreatus mushroom extract or a composition comprising a pleurotus ostretus mushroom extract

A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.

Methods of and compositions for inhibiting the proliferation of mammalian cells

The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The methods are effected by administering to the subject a therapeutically effective amount of a RNase6PL ribonuclease or close homologues thereof.

Recombinant human T2 RNase and uses thereof

A method of preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family.

Growing community of inventors

Rehovot, Israel

Betty Schwartz