Mogen International Nv

Bernardus Martinus Dekker

Andreas Hoekema

Peter Christiaan Sijmons

Teunis Cornelius Verwoerd

Barbara Schrammeijer

Peturs Josephus Van Den Elzen

This invention provides for a method to produce excreted and correctly processed heterologous protein-material in a plant host. The method comprises the step of transforming a plant host using a recombinant polynucleotide, which comprises the DNA sequences encoding the fully processed heterologous protein material, directly preceded by a DNA sequence coding for a plant signal peptide, and regulatory sequences necessary for the plant host to express the heterologous gene construct, resulting in excretion of the heterologous protein from the cell and correct cleavage of the N-terminal signal peptide, so that the mature heterologous protein produced by the plant host is identical to the corresponding protein produced in its authentic host.

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Gouda, Netherlands

Bernardus Martinus Dekker