University of California

Bernard H Choi

Christian Crouzet

Bruce J Tromberg

Robert H Wilson

Yama Akbari

Anthony J Durkin

Sean Michael White

Thomas E Milner

David Cuccia

J Stuart Nelson

Bruce Yee Yang

Amaan Mazhar

Tyler Rice

Petra Wilder-Smith

Byungjo Jung

Caitlin Regan

Cody Dunn

Electrophysiologic biomarkers for prognostication of neurological outcome are described herein. An inverse correlation was found between timing of a cortical spreading depolarization (SD) wave and neurological outcome as tested at 24 hours post-CPR. Additionally, a minor image of this SD was identified as a 'repolarization (RP) wave.' Quantifying features of SD and RP during cardiac arrest and cardiopulmonary resuscitation (CPR) provide important metrics for diagnosis and prognosis of neurological injury from hypoxia-ischemia and can serve as an early prognostication tool for predicting outcome at subsequent days after successful CPR. This discovery may also allow for novel therapeutic interventions to improve neurological recovery after hypoxia-ischemia insults.

Spreading depolarization and repolarization as biomarkers of neurological recovery after cardiac arrest

A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc.

Real-time methods to enable precision-guided CPR to improve neurological outcome and predict brain damage after ischemic injury and reperfusion

A portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.

Portable device for quantitative measurement of tissue autoregulation and neurovascular coupling using EEG, metabolism, and blood flow diagnostics

The technology relates to medical devices for monitoring and assessing vascular health. In one embodiment, the technology is an apparatus that attaches to a subject's finger comprising a heating and cooling component, a coherent source, a temperature sensor, an image detector, and/or a component for data control and management. In another embodiment, there is a component that alters local blood flow in the subject, and laser speckle contrast and photoplethysmography (PPG) signals from the altered blood flow in the subject are compared to monitor the vascular health of the subject.

Noninvasive method and apparatus for peripheral assessment of vascular health

The present invention relates to devices and methods of use thereof for real time blood flow measurements of skin. In one embodiment, the device is a compact laser speckle imaging, or LSI, system that is integrated with a dermatoscope. In another embodiment, the device allows the user to diagnose a disease or condition in an individual, or as part of an overall treatment regimen.

Handheld blood-flow imaging device

Disclosed herein are methods and apparatus for diagnosing a disease in the gingival region of an individual, comprising: quantitatively measuring blood flow or changes in blood flow in the gingival region of the individual, potentially comparing these data to that of a healthy subject, and diagnosing the disease based one of more of these quantities.

Methods and apparatus for the assessment of gingival blood flow

An apparatus for wide-field functional imaging (WiFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging

A digital imaging system provides color information of an entire port wine stain or other skin condition with a single image in CIE L*a*b* color space (L*, a*) derived from RGB pixel data (R, G, B). Cross-polarization optics produce marked reduction in specularly reflected light in the images. A patient positioning device allows for repeatable positioning of the patient's head or body portion. The digital nature of the system provides a near real-time mapping of melanin and erythema or other skin chromophore metrics. The cross-polarized diffuse reflectance color digital imaging system obtains subsurface skin color information and acquisition of facial images in a reproducible fashion at a fixed distance from an illumination source at optimized angles of view depending on the region of interest being imaged.

Growing community of inventors

Irvine, CA, United States of America

Bernard H Choi