Inex Pharmaceuticals Corporation

Acuitas Therapeutics, Inc.

The University of British Columbia

Alnylam Pharmaceuticals, Inc.

Arbutus Biopharma Corporation

Tekmira Pharmaceuticals Corporation

Barbara Mui

Michael J Hope

Steven Michial Ansell

Thomas D Madden

Marco A Ciufolini

Kim F Wong

Paulo Jia Ching Lin

Jianxin Chen

Pieter R Cullis

Srinivasulu Masuna

Xinyao Du

Christopher James Barbosa

Christopher J Barbosa

Muthiah Manoharan

Kallanthottathil G Rajeev

Sean C Semple

Masunu Srinivasulu

Marco A Cuifolini

Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.

Lipid nanoparticle formulations

The present invention provides compositions and methods which are useful for the introduction of polyanionic materials into cells. The compositions are mixtures of cationic compounds and neutral lipids which are typically formulated as liposomes. The cationic compounds are quaternary ammonium compounds wherein the nitrogen has two attached long chain alkyl groups, at least one of which is unsaturated. The methods for transfecting cells involve (a) contacting the polyanionic materials with the compositions above to form a polyanionic material-liposome complex, and (b) contacting the complex with the cells to be transfected.

Compositions for the introduction of polyanionic materials into cells

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Vancouver, Canada

Barbara Mui