Ichibiki Co., Ltd.

Tokyo Medical and Dental University

Asahi Kasei Pharma Corporation

Atsuhisa Nishimura

Toshihiko Kumazawa

Noriyuki Asai

Takahiro Adachi

Takeshi Matsuoka

Shigeyuki Imamura

Takuji Kouzuma

Shinichi Sakasegawa

Shinji Koga

Issei Yoshioka

Yoshiaki Ikura

Homare Itou

Takashi Kuroyanagi

Homare Ituo

Athat induces the production of interleukin-22 is provided. Thethat induces the production of interleukin-22.

Bacillus bacterium, interleukin-22 production inducing agent, skin barrier function enhancing agent

A lactic acid bacterium is provided which has high foodstuff suitability, easy to manufacture, and can increase the blood iron concentration, thereby improving anemia. A lactic acid bacterium of salt-tolerant that increases the blood iron concentration.

Lactic acid bacterium, blood iron increasing agent, and anemia improving agent

There is provided a salt-toleranthaving high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-toleranthaving an immunostimulatory action with viability and activation potency of B cells.

Salt-tolerant, method of culturing salt-tolerant, and immunostimulant

Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.

Method of measuring pyrophosphate

There is provided a method for specifically determining a glycated &#x3b2;-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated &#x3b2;-chain N-terminal without substantially cleaving a glycated amino acid or a glycated peptide from a glycated &#x3b1;-chain N-terminal of glycated hemoglobin or a fragment thereof is screened. The method of specifically determining a glycated &#x3b2;-chain N-terminal of glycated hemoglobin and the determination reagent kit are provided by using the protease obtained by the screening method. According to the present invention, a glycated &#x3b2;-chain N-terminal of glycated hemoglobin can specifically be determined without a separation operation.

Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof

Growing community of inventors

Toyohashi, Japan

Atsuhisa Nishimura