Evonik Degussa Gmbh

Degussa Aktiengesellschaft

Degussa - Huls Ag

National University of Ireland

Ashling McCormack

Kevin Burke

Cliona Stapelton

Bettina Mockel

Laurence Kieran Dunican

Rita Dunican, Legal Representative

Hermann Sahm

Lothar Eggeling

Achim Marx

Bettina Möckel

Bettina M&ouml;ckel

Anke Weissenborn

Laurence K Dunican

Bernd Moritz

Michael O'Donohue

L K Dunican

Cliona Stapleton

This application discloses methods for the preparation of L-amino acids, which comprises fermentation of a desired L-amino acid-producing bacteria in which at least the tal gene is amplified. In some embodiments, genes of the biosynthesis pathway of the desired L-amino acid are additionally amplified.

Process for the preparation of L-amino acids

The invention is directed to DNA sequences from coryneform bacteria, particularly, which encode a protein having transaldolase enzymatic activity. The invention also encompasses processes for the fermentative production of L-amino acids using bacteria in which a gene encoding transaldolase is amplified.

Process for the preparation of L-amino acids by overexpressing the tal gene encoding transaldolase

The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in

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Nucletoide sequences which code for the opcA gene

The invention is directed to DNA sequences from coryneform bacteria which encode a protein having transaldolase enzymatic activity. The invention also encompasses methods for the fermentative production of L-amino acids using bacteria in which the gene encoding transaldolase is amplified.

Nucleotide sequences which code for the tal gene

The present invention is directed to isolated polynucleotides coding for phosphoglucose isomerase (pgi) from coryneform bacteria. In addition, the invention includes methods for increasing the metabolic flux through pentose phosphate cycle of bacteria by reducing or eliminating the activity of pgi. These methods may be used to increase the fermentative production of nucleotides, vitamins and amino acids.

Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)

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Athlone, Ireland

Ashling McCormack