Tagworks Pharmaceuticals B.v.

Arthur Henry Antoon Marie Van Onzen

Wolter Ten Hoeve

Henricus Marie Janssen

Ronny Mathieu Versteegen

Marc Stefan Robillard

Raffaella Rossin

Freek Johannes Maria Hoeben

Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct Cbound to a Trigger T, the kit having a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine having a Construct Cbound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of the Construct.

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NIJMEGEN, Netherlands

Arthur Henry Antoon Marie Van Onzen