Hoffmann-la Roche Inc.

Roche Diagnostics Operations, Inc.

F. Hoffmann-la Roche Ag

Armin Ruf

Michelangelo Scalone

Wolfgang Haap

Paul Hebeisen

Holger Kuehne

Eric Argirios Kitas

Harald Sobek

Rainer Mueller

Urs Schwitter

Johann-Peter Thalhofer

Olaf Grassmann

Michael Greif

Shaoning Wang

Manfred Schmidt

Stefan Abrecht

Franziska E Rohrer

Francois Montavon

Regina Moog

Andre Bubendorf

Stephan Goetzoe

Christian Rudolph

Philipp Christoph Kohler

The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.

T7 RNA polymerase variants with enhanced thermostability

Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R, R, m and n have the meaning given in claimand which can be used in the form of pharmaceutical compositions.

Sulfonamide derivatives

The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.

Salt and polymorphs of a DPPIV inhibitor

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Freiburg, Germany

Armin Ruf