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Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione—instituto Dermopatico Dell'immacolata

Provincia Italiana Della Congregzaione Dei Figli Dell'immacolata Concezione - Istituto Dermopatico Dell'immacolata

Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione-istituto Dermopatico Dell'immacolata

Antonio Facchiano

John Paul Ranieri

Marco Scoccianti

Diane Lee Anderson

Maurizio Capogrossi Colognesi

Francesco Facchiano

Ivan Rossi

Angelo Facchiano

Rita Casadio

An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.

Prosthetic grafts

A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.

Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif &ldquo;arginine-glycine-aspartic acid&rdquo; (that is a potent inhibitor, in vivo and in vitro, of cellular adhesion) In vitro experimentation demonstrated that said molecules are efficient inhibitors of RASMC adhesion, proliferation and migration.

RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects

Growing community of inventors

Rome, Italy

Antonio Facchiano