Intercept Pharmaceuticals, Inc.

Antimo Gioiello

Roberto Pellicciari

Françoise Perron-Sierra

Antonio Macchiarulo

Klaus Seedorf

Gabriel Galvin

Myoung Goo Kim

Ronald D Lewis, Ii

Mathew Yanik

Frederik Ronald Leusink

Bartjan Koning

Thomas Hensel

The present application provides a compound of formula I: or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R-R, m, n, p, andare as described herein. The present invention relates generally to FXR modulators and to methods of making and using said compounds.

Farnesoid X receptor modulators

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

TGR5 modulators and methods of use thereof

The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.

3-desoxy derivative and pharmaceutical compositions thereof

The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I  or pharmaceutically acceptable salt, hydrate, solvate or amino acid, sulfate or glucuronide conjugate, or prodrug thereof, comprising the step of reacting a compound of formula I-4 with a halogenating reagent to provide a compound of formula I-5a 

Methods and intermediates for the preparation of bile acid derivatives

The present application relates to a method of preparing compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, Ris H, &#x3b1;-OH, &#x3b2;-OH, or an oxo group. 

Methods for preparation of bile acids and derivatives thereof

The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof.

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Perugia, Italy

Antimo Gioiello