Mitokor, Inc.

University of California

Migenix, Inc.

Anne N Murphy

Robert E Davis

William Christensen Clevenger

Sandra Eileen Wiley

Alexander Y Andreyev

Luciano G Frigeri

Soumitra S Ghosh

Gonul Velicelebi

James A Dykens

Robert Terkeltaub

Andrew E Granston, Jr

Gonul Velecelebi

Wei Yuan Hsieh

Steven J Bensinger

Amy K Stout

Ajit Srinivas Divakaruni

Methods and agents for modulating intracellular coenzyme A levels are described for therapeutic purposes. Increasing intracellular coenzyme A increases alternate macrophage activation resulting in suppression or resolution of an immune response for benefit in treating inflammatory diseases. Decreasing intracellular coenzyme A levels decreases alternate macrophage activation which is beneficial in treating NASH/NAFLD and various fibrotic diseases as well as reversing immune suppressing activity of tumor-associated immune cells such as macrophages for the treatment of cancer.

Methods and agents for modulating inflammation

The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.

Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass

The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.

Screening assays using intramitochondrial calcium

Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

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Encinitas, CA, United States of America

Anne N Murphy